Mustargen®
(mechlorethamine HCl for injection)

• Mustargen is a biologic alkylating agent in the group of medicines known as antineoplastics.
• Mustargen is available in vials containing 10 mg of mechlorethamine hydrochloride triturated with sodium chloride q.s. 100 mg.

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Indications and Usage
Trituration of MUSTARGEN® (methlorethamine HCl for injection), administered intravenously, is indicated for the palliative treatment of Hodgkin’s disease (Stages III and IV), lymphosarcoma, chronic myelocytic or chronic lymphocytic leukemia, polycythemia vera, mycosis fungoides, and bronchogenic carcinoma.

MUSTARGEN, administered intrapleurally, intraperitoneally, or intrapericardially, is indicated for the palliative treatment of metastatic carcinoma resulting in effusion.

Important Safety Information

MUSTARGEN is contraindicated in the presence of known infectious diseases and in patients who have had previous anaphylactic reactions to Mustargen.  MUSTARGEN therapy may contribute to rapid and extensive amyloidosis.  Therapy with alkylating agents such as MUSTARGEN may be associated with an increased incidence of a second malignant tumor, especially when such therapy is combined with other antineoplastic agents or radiation therapy. Caution should be used when treating patients with leucopenia, thrombocytopenia and anemia.  Irradiation of areas after a short course of MUSTARGEN may lead to hematologic complications.  MUSTARGEN has been reported to have immunosuppressive activity.  Hyperuricemia may develop during MUSTARGEN therapy.  Extreme caution should be used in exceeding the recommended dose. Check renal, hepatic and bone marrow functions frequently.  Use in pediatric patients has not been studied.  Dose selection for elderly patients should be cautious, usually starting at the low end of the dosing range. 

Adverse reactions reported include thrombosis, thrombophlebitis, hypersensitivity, nausea, vomiting, jaundice, alopecia, vertigo, tinnitus, and various chromosomal abnormalities.

For more information, please see Full Prescribing Information including Boxed Warning.

® Trademark of Lundbeck Inc., Deerfield, IL 60015, U.S.A.